The DNA methylation profile of cancer cells is frequently characterized by global
hypomethylation and simultaneous hypermethylation of selected CpG island gene …

DNA methylation is an epigenetic modification of the DNA sequence and thus does not
change the genetic code but affects chromosomal stability and gene expression. DNA …

Cancer-associated disturbances of regulated DNA methylation include both global
hypomethylation and gene-specific (often even cancer-specific) hypermethylation. Both …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

Dysregulation of DNA methylation in B cells has been observed during their neoplastic
transformation and therefore closely associated with various B-cell malignancies including …

Over the last 30 years, studies of aberrant DNA methylation in hematologic malignancies
have been dominated by the primary focus of understanding promoter hypermethylation …

Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …

Abstract Changes in genomic methylation and its significance in carcinogenesis is in the
spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …