DNA methylation patterns are frequently altered in cancer cells as compared to normal cells.
A large body of research associates these DNA methylation aberrations with cancer …

Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

DNA methylation inhibitors have become the mainstay for treatment of certain
haematological malignancies. In addition to their abilities to reactivate genes, including …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Targeting DNA hypermethylation, using nucleoside analogs, is an efficient approach to
reprogram cancer cell epigenome leading to reduced proliferation, increased differentiation …

Chronic myeloid leukemia (CML) is a hematopoietic stem cell malignancy characterized by
the expression of the BCR–ABL1 fusion gene with different chimeric transcripts. Despite the …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …