Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …

Knowledge of epigenetic alterations in cancer is rapidly increasing due to the development
of genome-wide techniques for their identification. DNA methylation is the best understood …

The past decade has seen an explosion of interest in the epigenetics of cancer, with an
increasing understanding that this form of genomic modification plays a critical role in …

DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

Acute myeloid leukemia (AML) is characterized by an impaired differentiation process
leading to an accumulation of immature blasts in the blood. One feature of cytogenetically …

Distinct DNA methylation signatures, related to different prognosis, have been observed
across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive …

The myelodysplastic syndromes (MDS) are a group of hematologic disorders characterized
by ineffective hematopoiesis and increased risk of transformation to acute myeloid leukemia …

Epigenetic mechanisms synergize with genetic alterations in modulating gene expression
patterns in cancer cells. While epigenetic alterations are reversible genetic modifications are …

Epigenetic events like DNA methylation are known to regulate gene expression, and
dysregulation of these events is associated with neoplastic proliferation. Here, we provide a …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …