Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …

Dramatic epigenetic changes take place during mammalian differentiation from the naïve
pluripotent state including the silencing of one of the two X chromosomes in female cells …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

Induced pluripotent stem cells (iPSCs) acquire embryonic stem cell (ESC)-like epigenetic
states, including the X chromosome. Previous studies reported that human iPSCs retain the …

Acquisition of the pluripotent state coincides with epigenetic reprogramming of the X-
chromosome. Female embryonic stem cells are characterized by the presence of two active …

X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as
pluripotent cells differentiate. Once established, XCI is stably propagated, but can be …

Reprogramming to iPSCs resets the epigenome of somatic cells, including the reversal of X
chromosome inactivation. We sought to gain insight into the steps underlying the …

X chromosome inactivation (XCI) is a striking example of developmentally regulated, wide‐
range heterochromatin formation that is initiated during early embryonic development. XCI is …

The process of X chromosome inactivation (XCI) during reprogramming to produce human
induced pluripotent stem cells (iPSCs), as well as during the extensive programming that …

X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic
cells of female mammals, has revealed important advances in our understanding of …