The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells
K Shirane, K Kurimoto, Y Yabuta, M Yamaji, J Satoh… - Developmental cell, 2016 - cell.com
Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …
Global profiling of DNA methylation erasure in mouse primordial germ cells
S Guibert, T Forné, M Weber - Genome research, 2012 - genome.cshlp.org
Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …
Comparative principles of DNA methylation reprogramming during human and mouse in vitro primordial germ cell specification
F von Meyenn, RV Berrens, S Andrews, F Santos… - Developmental cell, 2016 - cell.com
Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …
which resets genomic potential and establishes an epigenetic ground state. Here we …
High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
H Kobayashi, T Sakurai, F Miura, M Imai… - Genome …, 2013 - genome.cshlp.org
Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …
although the targets of this process, including DNA demethylation and de novo methylation …
DNA demethylation dynamics in the human prenatal germline
Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …
A unique gene regulatory network resets the human germline epigenome for development
Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …
development. We show that the transcriptional program of hPGCs is distinct from that in …
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
P Hajkova, SJ Jeffries, C Lee, N Miller, SP Jackson… - Science, 2010 - science.org
Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …
[HTML][HTML] Epigenetic reprogramming in mouse primordial germ cells
Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …
embryos, plays a crucial role in regulating genome functions at critical stages of …