[PDF][PDF] Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing
R Yan, C Gu, D You, Z Huang, J Qian, Q Yang… - Cell Stem Cell, 2021 - cell.com
Developing female human germ cells undergo genome-wide epigenetic reprogramming, but
de novo DNA methylation dynamics and their interplay with chromatin states and …
de novo DNA methylation dynamics and their interplay with chromatin states and …
[PDF][PDF] Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage
Investigations of the human germline and programming are challenging because of limited
access to embryonic material. However, the pig as a model may provide insights into …
access to embryonic material. However, the pig as a model may provide insights into …
DNA methylation reprogramming of functional elements during mammalian embryonic development
DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …
reprogramming of functional elements has not been fully investigated during mammalian …
Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
Gametes are highly specialized cells that can give rise to the next generation through their
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo
Parental DNA methylation and histone modifications undergo distinct global reprogramming
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …
[PDF][PDF] DUSP9 modulates DNA hypomethylation in female mouse pluripotent stem cells
Blastocyst-derived embryonic stem cells (ESCs) and gonad-derived embryonic germ cells
(EGCs) represent two classic types of pluripotent cell lines, yet their molecular equivalence …
(EGCs) represent two classic types of pluripotent cell lines, yet their molecular equivalence …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
Reconstituting the transcriptome and DNA methylome landscapes of human implantation
Implantation is a milestone event during mammalian embryogenesis. Implantation failure is
a considerable cause of early pregnancy loss in humans. Owing to the difficulty of obtaining …
a considerable cause of early pregnancy loss in humans. Owing to the difficulty of obtaining …
The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation
The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …
[PDF][PDF] PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic
reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5 …
reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5 …