DNA methylation is necessary for the silencing of endogenous retrotransposons and the
maintenance of monoallelic gene expression at imprinted loci and on the X chromosome …

DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …

Mammalian DNA methylation plays an essential role in development. To date, only
snapshots of different mouse and human cell types have been generated, providing a static …

Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …

Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …

Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …

Background Genomic methylation patterns are established during gametogenesis, and
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …

In mammals, the canonical somatic DNA methylation landscape is established upon
specification of the embryo proper and subsequently disrupted within many cancer types …

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …