DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages
DM Maatouk, LD Kellam, MRW Mann, H Lei, E Li… - 2006 - journals.biologists.com
DNA methylation is necessary for the silencing of endogenous retrotransposons and the
maintenance of monoallelic gene expression at imprinted loci and on the X chromosome …
maintenance of monoallelic gene expression at imprinted loci and on the X chromosome …
Germline-derived DNA methylation and early embryo epigenetic reprogramming: the selected survival of imprints
D Monk - The international journal of biochemistry & cell biology, 2015 - Elsevier
DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …
processes. During development epigenetic reprograming takes place during gametogenesis …
[HTML][HTML] Tracing dynamic changes of DNA methylation at single-cell resolution
Y Stelzer, CS Shivalila, F Soldner, S Markoulaki… - Cell, 2015 - cell.com
Mammalian DNA methylation plays an essential role in development. To date, only
snapshots of different mouse and human cell types have been generated, providing a static …
snapshots of different mouse and human cell types have been generated, providing a static …
[HTML][HTML] In vitro reconstitution of epigenetic reprogramming in the human germ line
Y Murase, R Yokogawa, Y Yabuta, M Nagano, Y Katou… - Nature, 2024 - nature.com
Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
[HTML][HTML] Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice
Y Seki, K Hayashi, K Itoh, M Mizugaki, M Saitou… - Developmental …, 2005 - Elsevier
Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …
[HTML][HTML] Beyond DNA: programming and inheritance of parental methylomes
JA Hackett, MA Surani - Cell, 2013 - cell.com
Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …
[HTML][HTML] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
H Kobayashi, T Sakurai, M Imai, N Takahashi… - PLoS …, 2012 - journals.plos.org
Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …
development and genomic imprinting in mammals. Here, we report single-base resolution …
[HTML][HTML] Dynamic instability of genomic methylation patterns in pluripotent stem cells
Background Genomic methylation patterns are established during gametogenesis, and
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …
Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
In mammals, the canonical somatic DNA methylation landscape is established upon
specification of the embryo proper and subsequently disrupted within many cancer types …
specification of the embryo proper and subsequently disrupted within many cancer types …
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …