Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis
O Bogdanović, SW Long, SJ van Heeringen… - Genome …, 2011 - genome.cshlp.org
DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …
repression. Next-generation sequencing of purified methylated DNA obtained from early …
Epigenetic reprogramming in the germline: towards the ground state of the epigenome
P Hajkova - … Transactions of the Royal Society B …, 2011 - royalsocietypublishing.org
Epigenetic reprogramming in the germline provides a developmental model to study the
erasure of epigenetic memory as it occurs naturally in vivo in the course of normal …
erasure of epigenetic memory as it occurs naturally in vivo in the course of normal …
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape
Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
Impairment of DNA methylation maintenance is the main cause of global demethylation in naive embryonic stem cells
Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …
Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage
L Chavez, J Jozefczuk, C Grimm, J Dietrich… - Genome …, 2010 - genome.cshlp.org
The generation of genome-wide data derived from methylated DNA immunoprecipitation
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …
MERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts …
through a state characterized by decondensed chromatin and expression of transcripts …
Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos
Epigenetic alterations are increasingly recognized as causes of human cancers and
disease. These aberrations are likely to arise during genomic reprogramming in mammalian …
disease. These aberrations are likely to arise during genomic reprogramming in mammalian …
An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …
embryogenesis. Most transposons become hypomethylated, raising the question of their …
Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing
DNA methylation is crucial for a wide variety of biological processes, yet no technique
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
DNA methylation dynamics of the human preimplantation embryo
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …
stably distributed across the genome, with local, cell-type-specific regulation directed by …