Membrane cofactor protein (MCP, CD46) is a widely expressed transmembrane
complement regulator. As does the soluble regulator factor H, it inhibits complement …

A subgroup of patients with the most severe form of the Hemolytic Uremic Syndrome (HUS)
presents mutations in the complement regulatory protein factor H. The functional analyses of …

Atypical hemolytic and uremic syndrome (aHUS) is a severe disease strongly associated
with genetic abnormalities in the complement alternative pathway. In renal …

Incidents of hemolytic uremic syndrome (HUS) include a subset of patients that exhibit
mutations in C factor H. These mutations cluster in the C-terminal domains of factor H where …

A male child initially presented with atypical hemolytic uremic syndrome (HUS) at the age of
4 months and progressed within weeks to end stage renal disease (ESRD). At the age of 2 …

Atypical hemolytic uremic syndrome is a disease that is characterized by microangiopathic
hemolytic anemia, thrombocytopenia, and acute renal failure. Mutations in the complement …

Atypical hemolytic uremic syndrome (aHUS) is a disorder characterized by hemolytic
anemia, thrombocytopenia, and acute renal failure. Mutations, polymorphisms, and copy …

Background Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a high
recurrence rate after kidney transplantation. In most cases, aHUS are caused by genetic …

Familial hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP)
carry a very poor outcome and have been reported in association with decreased serum …

For thrombotic microangiopathies (TMAs), the diagnosis of atypical hemolytic uremic
syndrome (aHUS) is made by ruling out Shiga toxin-producing Escherichia coli (STEC) …