We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from chronic
lymphocytic leukemia (CLL) patients and normal control samples using reduced …

We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic
leukemia (CLL) using methylated CpG island amplification (MCA) coupled with a promoter …

Aims: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy that
clinically ranges from indolent to rapidly progressive. CLL, like other cancers, can be …

Abstract Background Methyl-CpG-binding domain protein enriched genome-wide
sequencing (MBD-Seq) is a robust and powerful method for analyzing methylated CpG-rich …

B cell receptor (BCR) signaling is a key for survival of chronic lymphocytic leukemia (CLL)
cells, and BCR signaling inhibitors are clinically active. However, relapse and resistance to …

We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

Global hypomethylation and regional hypermethylation are well-known epigenetic features
of cancer; however, in chronic lymphocytic leukemia (CLL), studies on genome-wide …

Background Chronic lymphocytic leukemia (CLL) has been a good model system to
understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More …

In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression
patterns; however, knowledge is limited regarding the extent to which methylation changes …

Over the past two decades, aberrant DNA methylation has emerged as a key player in the
pathogenesis of chronic lymphocytic leukemia (CLL), and knowledge regarding its …