Polycomb complexes and epigenetic states

YB Schwartz, V Pirrotta - Current opinion in cell biology, 2008 - Elsevier
Important advances in the study of Polycomb Group (PcG) complexes in the past two years
have focused on the role of this repressive system in programing the genome. Genome-wide …

A new world of Polycombs: unexpected partnerships and emerging functions

YB Schwartz, V Pirrotta - Nature Reviews Genetics, 2013 - nature.com
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

Context-specific Polycomb mechanisms in development

JJ Kim, RE Kingston - Nature Reviews Genetics, 2022 - nature.com
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Polycomb group complexes–many combinations, many functions

TK Kerppola - Trends in cell biology, 2009 - cell.com
Polycomb Group (PcG) proteins are transcription regulatory proteins that control the
expression of a variety of genes from early embryogenesis through birth to adulthood. PcG …

Regulation of gene transcription by Polycomb proteins

S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …

Programming of gene expression by Polycomb group proteins

C Köhler, CBR Villar - Trends in cell biology, 2008 - cell.com
Polycomb group (PcG) complexes maintain epigenetically repressed states that need to be
reprogrammed when cells become committed to differentiation. In contrast to the previously …

Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

VK Rajasekhar, M Begemann - Stem cells, 2007 - academic.oup.com
The acquisition and maintenance of cell fate are essential for metazoan growth and
development. A strict coordination between genetic and epigenetic programs regulates cell …

Division of labor in polycomb group repression

SS Levine, IFG King, RE Kingston - Trends in biochemical sciences, 2004 - cell.com
The epigenetic maintenance of gene expression patterns is essential for developing and
maintaining the diverse types of cell that cooperate to form the larger organism. Recent data …

Biochemical mechanisms of gene regulation by polycomb group protein complexes

J Müller, P Verrijzer - Current opinion in genetics & development, 2009 - Elsevier
Polycomb group (PcG) proteins are transcriptional repressors that control expression of
developmental regulator genes in animals and plants. Recent advances in our …

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice

B Schuettengruber, G Cavalli - Development, 2009 - journals.biologists.com
Polycomb group (PcG) protein complexes dynamically define cellular identity through the
regulation of key developmental genes. Important advances in the PcG field have come from …