von Hippel-Lindau disease is a hereditary cancer syndrome predisposing carriers to the
development of a panel of highly vascularized tumors such as central nervous system and …

Kidney cancer, blood vessel tumors (hemangioblastomas), and adrenal tumors
(pheochromocytomas) are features of von Hippel–Lindau disease, which is caused by …

Abstract von Hippel–Lindau (VHL) disease is characterized by biallelic inactivation of the
VHL gene leading to abnormal or absent VHL protein function, and constitutive activation of …

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene is responsible for the
development of renal carcinomas, pheochromocytomas and tumours in other organs. The …

Von Hippel–Lindau (VHL) disease is a rare autosomal dominant syndrome (1/36,000 live
births) with highly penetrance that predispose to the development of a panel of highly …

Germ line mutations in the VHL tumor-suppressor gene cause von Hippel–Lindau (VHL)
disease, a hereditary neoplastic disease associated with clear-cell renal-cell carcinomas …

Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes
including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited …

Abstract Purpose of Review In this review, we discuss the key molecular and clinical
developments in VHL disease that have the potential to impact on the natural history of the …

Germ line mutations of the VHL gene have been identified as the root cause of this disease.
6 Mutations and/or aberrations of the same gene have been identified in the majority of …

Abstract von Hippel-Lindau disease, which is characterized by an increased risk of
hemangioblastomas, clear cell renal carcinomas, and pheochromocytomas, is caused by …