Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …