[PDF][PDF] DNA methylation signatures within the human brain

C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
DNA methylation is a heritable modification of genomic DNA central to development,
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …

Population-specificity of human DNA methylation

HB Fraser, LL Lam, SM Neumann, MS Kobor - Genome biology, 2012 - Springer
Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …

Tissue-specific variation in DNA methylation levels along human chromosome 1

C De Bustos, E Ramos, JM Young, RK Tran… - Epigenetics & …, 2009 - Springer
Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …

[PDF][PDF] Genetic control of individual differences in gene-specific methylation in human brain

D Zhang, L Cheng, JA Badner, C Chen, Q Chen… - The American Journal of …, 2010 - cell.com
We have observed extensive interindividual differences in DNA methylation of 8590 CpG
sites of 6229 genes in 153 human adult cerebellum samples, enriched in CpG island" …

[HTML][HTML] Comparison of whole-genome DNA methylation patterns in whole blood, saliva, and lymphoblastoid cell lines

TM Thompson, D Sharfi, M Lee, CM Yrigollen… - Behavior genetics, 2013 - Springer
Epigenetic mechanisms, including DNA methylation, that underlie neuropsychiatric
conditions have become a promising area of research. Most commonly used DNA sources …

Dynamic DNA methylation across diverse human cell lines and tissues

KE Varley, J Gertz, KM Bowling, SL Parker… - Genome …, 2013 - genome.cshlp.org
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

[PDF][PDF] DNA methylation signatures in development and aging of the human prefrontal cortex

S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain
regions to mature. To investigate the role of epigenetics in the development of PFC, we …

Distinct DNA methylation changes highly correlated with chronological age in the human brain

DG Hernandez, MA Nalls, JR Gibbs… - Human molecular …, 2011 - academic.oup.com
Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …

Spatial, temporal and interindividual epigenetic variation of functionally important DNA methylation patterns

E Schneider, G Pliushch, N El Hajj… - Nucleic acids …, 2010 - academic.oup.com
DNA methylation is an epigenetic modification that plays an important role in gene
regulation. It can be influenced by stochastic events, environmental factors and …

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue-and individual-specific DNA methylation patterns

HM Byun, KD Siegmund, F Pan… - Human molecular …, 2009 - academic.oup.com
DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …