[HTML][HTML] Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
[PDF][PDF] Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution
DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
MethylomeDB: a database of DNA methylation profiles of the brain
Y Xin, B Chanrion, AH O'Donnell, M Milekic… - Nucleic acids …, 2012 - academic.oup.com
Abstract MethylomeDB (http://epigenomics. columbia. edu/methylomedb/index. html) is a
new database containing genome-wide brain DNA methylation profiles. DNA methylation is …
new database containing genome-wide brain DNA methylation profiles. DNA methylation is …
Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
A Kozlenkov, P Roussos, A Timashpolsky… - Nucleic acids …, 2014 - academic.oup.com
Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
JM Ordway, JA Bedell, RW Citek, A Nunberg… - …, 2006 - academic.oup.com
Using a unique microarray platform for cytosine methylation profiling, the DNA methylation
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …
Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal …
DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
A DNA methylation fingerprint of 1628 human samples
AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …
particular genomic loci in a limited number of human samples and pathological conditions …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
[HTML][HTML] DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …