DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

The behavior of epigenetic mechanisms in the brain is obscured by tissue heterogeneity and
disease-related histological changes. Not accounting for these confounders leads to biased …

The brain is built from a large number of cell types which have been historically classified
using location, morphology and molecular markers. Recent research suggests an important …

A fundamental challenge in the post-genome era is to understand and annotate the
consequences of genetic variation, particularly within the context of human tissues. We …

Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …

Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …

DNA methylation is a chemical modification that occurs predominantly on CG dinucleotides
in mammalian genomes. However, recent studies have revealed that non-CG methylation …

Alterations in epigenetic landscapes are hallmarks of many complex human diseases, yet, it
is often challenging to assess the underlying mechanisms and causal link with clinical …

Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …

Recent research suggests that epigenetic alterations involving DNA methylation can be
causative for neurodevelopmental, growth and metabolic disorders. Although …