DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …

Epigenetics is one of the key areas of future research that can elucidate how genomes work.
It combines genetics and the environment to address complex biological systems such as …

In spite of intense interest in how altered epigenetic processes including DNA methylation
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …

Background Perturbation of DNA methylation is frequent in cancers and has emerged as an
important mechanism involved in tumorigenesis. To determine how DNA methylation is …

It is well known that a variety of genetic changes influence the development and progression
of cancer. These changes may result from inherited or spontaneous mutations that are not …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and
the progression of many cancers, and it plays an important role in gametic imprinting. To …

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …