Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

DNA methylation is a vital epigenetic mark that participates in establishing and maintaining
chromatin structures and regulates gene transcription during mammalian development and …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …

DNA methylation of promoter sequences is a repressive epigenetic mark that down-
regulates gene expression. However, DNA methylation is more prevalent within gene …

DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …