The trust that authors place in editors, and editors in reviewers, creates a precious
opportunity to strengthen manuscripts and advance science. The Lancet values deeply the …

Opinion. Comments on the use of randomized controlled trials (RCT). Such trials becoming
the gold standard in clinical medicine for the assessment of new interventions; …

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scientific quality, as well as the humanistic relevance, of patient-oriented research cannot be …

The protocol is an important document that details the background, methods, ethical
considerations, and administration of a clinical trial. 1 The information contained in the …

If a new clinical trial is to be justifiable both scientifically and ethically it should be designed
in the light of an assessment of relevant previous research, ideally a systematic review. 1 …

May 20, 2005, saw the first ever international clinical trials day, 1 celebrating the contribution
of James Lind2 to the concept of medical research and recognising that biomedical research …

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Imagine if the entire edifice of knowledge in medicine was built upon a falsehood.
Systematic reviews are said to be the highest standard of evidence-based health care …

William Harvey (1578–1657) was one of a group of 17th century natural philosophers who
were no longer prepared to accept the authority of Aristotle, Plato, and Galen as a reliable …

Are meta-analyses the brave new world, or are the critics of such combined analyses right to
say that the biases inherent in clinical trials make them uncombinable? Negative trials are …