DNA methylation was traditionally viewed as a static mechanism required during cell fate
determination. This view has been challenged and it is now accepted that DNA methylation …

The establishment of synaptic plasticity and long-term memory requires lasting cellular and
molecular modifications that, as a whole, must endure despite the rapid turnover of their …

Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …

Learning and memory are two of the fundamental cognitive functions that confer us the
ability to accumulate knowledge from our experiences. Although we use these two mental …

Cytosine DNA methylation is a stable epigenetic modification with established roles in
regulating transcription, imprinting, female X-chromosome inactivation, and silencing of …

Dynamic variations in DNA methylation regulate neuronal gene expression in an experience-
dependent manner. Although DNA methylation has been implicated in synaptic plasticity …

Adult neurogenesis enables the life‐long addition of functional neurons to the hippocampus
and is regulated by both cell‐intrinsic molecular programs and behavioral activity. De novo …

Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in
learning and memory. Methylation of cytosine nucleotides has historically been considered …

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …

Recent observations suggest that DNA methylation plays an important role in memory and
long-term potentiation (LTP) in the hippocampus and is involved in programming the …