Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Y Li, C Li, T Luo, T Yue, W Xiao, L Yang… - Journal of …, 2023 - Taylor & Francis
With the increasing of altitude activities from low-altitude people, the study of high altitude
cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness …

[HTML][HTML] Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

TT Song, YH Bi, YQ Gao, R Huang, K Hao, G Xu… - Journal of …, 2016 - Springer
Background High-altitude cerebral edema (HACE) is the severe type of acute mountain
sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the …

Establishment and evaluation of an experimental animal model of high altitude cerebral edema

P Guo, H Luo, Y Fan, Y Luo, Q Zhou - Neuroscience letters, 2013 - Elsevier
The aim of our study was to develop a model of high altitude cerebral edema (HACE) using
an acute, hypobaric hypoxia environment combined with exhaustive exercise. Forty healthy …

High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?

REF Turner, H Gatterer, M Falla… - Journal of Applied …, 2021 - journals.physiology.org
High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

The role of oxidative stress and neuroinflammatory mediators in the pathogenesis of high-altitude cerebral edema in rats

RA Shushanyan, NV Avtandilyan, AV Grigoryan… - Respiratory Physiology …, 2024 - Elsevier
High-altitude environments present extreme conditions characterized by low barometric
pressure and oxygen deficiency, which can disrupt brain functioning and cause edema …

High altitude cerebral edema and acute mountain sickness: a pathophysiology update

PH Hackett - Hypoxia: into the next millennium, 1999 - Springer
The diagnosis, treatment and prevention of high altitude cerebral edema (HACE) are fairly
well established. The major unresolved issues are 1) the pathophysiology, 2) the individual …

Expression profile of cytokines and chemokines in a mouse high-altitude cerebral edema model

Z Shi, X Jiang, Y Geng, X Yue, J Gao… - International …, 2023 - journals.sagepub.com
Introduction High-altitude cerebral edema (HACE) is considered to be the end-stage of
acute mountain sickness (AMS); however, its pathophysiological mechanism remains …

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice

Y Zhou, X Huang, T Zhao, M Qiao, X Zhao… - Brain, Behavior, and …, 2017 - Elsevier
High altitude cerebral edema (HACE) is a life-threatening illness that develops during the
rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing …

The Effect of High-Altitude Hypoxia on Neuropsychiatric Functions

B Liu, M Yuan, M Yang, H Zhu… - High Altitude Medicine & …, 2024 - liebertpub.com
Liu, Bo, Minlan Yuan, Mei Yang, Hongru Zhu, and Wei Zhang. The effect of high-altitude
hypoxia on neuropsychiatric functions. High Alt Med Biol. 25: 26–41, 2024. Background: In …

[HTML][HTML] Neurological dysfunction and diseases in high altitude

X Wen, P Long - Frontiers in Neurology, 2024 - frontiersin.org
High altitude attracts a large number of people, including travelers, athletes, military
personnel, and businessmen. However, the high altitude environment is a serious challenge …