Recent studies show that subtle variations in thyroid function, including subclinical thyroid
dysfunction, and even variation in thyroid function within the normal range, are associated …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Context Genetic factors are major determinants of thyroid function. Over the last two
decades, multiple genetic variants have been associated with variations in normal range …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …

Background: The thyroid plays a key role in development and homeostasis, but it has been
difficult to establish causality with diseases and phenotypic traits because of several …

Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …

Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …

Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …