Genetic alterations of DNA methylation machinery in human diseases
T Hamidi, AK Singh, T Chen - Epigenomics, 2015 - Taylor & Francis
DNA methylation plays a critical role in the regulation of chromatin structure and gene
expression and is involved in a variety of biological processes. The levels and patterns of …
expression and is involved in a variety of biological processes. The levels and patterns of …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
[HTML][HTML] DNA methyltransferases and their roles in tumorigenesis
W Zhang, J Xu - Biomarker research, 2017 - Springer
DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
Mammalian DNA methyltransferases: new discoveries and open questions
As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
[HTML][HTML] DNA methyltransferases: from evolution to clinical applications
VM Del Castillo Falconi, K Torres-Arciga… - International journal of …, 2022 - mdpi.com
DNA methylation is an epigenetic mark that living beings have used in different
environments. The MTases family catalyzes DNA methylation. This process is conserved …
environments. The MTases family catalyzes DNA methylation. This process is conserved …
[HTML][HTML] Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …
[HTML][HTML] Dnmt3b prefers germ line genes and centromeric regions: lessons from the ICF syndrome and cancer and implications for diseases
EL Walton, C Francastel, G Velasco - Biology, 2014 - mdpi.com
The correct establishment and maintenance of DNA methylation patterns are critical for
mammalian development and the control of normal cell growth and differentiation. DNA …
mammalian development and the control of normal cell growth and differentiation. DNA …
[HTML][HTML] DNMT3B functions: novel insights from human disease
M Gagliardi, M Strazzullo… - Frontiers in cell and …, 2018 - frontiersin.org
DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …
structure. Its proper establishment and maintenance are essential for mammalian …
The role of genetics in the establishment and maintenance of the epigenome
C Huidobro, AF Fernandez, MF Fraga - Cellular and Molecular Life …, 2013 - Springer
Epigenetic mechanisms play an important role in gene regulation during development. DNA
methylation, which is probably the most important and best-studied epigenetic mechanism …
methylation, which is probably the most important and best-studied epigenetic mechanism …