Progressive renal enlargement due to the growth of innumerable fluid-filled cysts is a central
pathophysiological feature of autosomal dominant polycystic kidney disease (ADPKD) …

In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe
interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular …

In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix
production contributes to cyst growth and fibrosis, leading to progressive deterioration of …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous
fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that …

Periostin is a matricellular protein that is expressed in several tissues during embryonic
development; however, its expression in adults is mostly restricted to collagen-rich …

Matricellular proteins participate in the pathogenesis of chronic kidney diseases. We
analyzed glomerular gene expression profiles from patients with proteinuric diseases to …

Background Periostin acts as an adhesion molecule during bone formation. Knowledge of
its expression in kidney injury is scant. Methods We investigated periostin function and …

Background: Periostin is responsible for tissue regeneration, fibrosis, and wound healing via
its interaction with integrin. Recently, the role of periostin has been shown to contribute to …

Purpose: Periostin is a secreted extracellular matrix protein that is differentially expressed in
the developing kidney. We analyzed the temporal-spatial expression of periostin in the …

Increased renal expression of periostin, a protein normally involved in embryonic and dental
development, correlates with the decline of renal function in experimental models and …