Melatonin (n-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by
the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second …

Melatonin is a candidate neuroprotective drug for ischaemic stroke. Any decision to proceed
to clinical trial for such drugs should be based on an unbiased assessment of all available …

The brain is highly susceptible to focal or global ischemia. Unless ischemia is promptly
reversed, reperfusion produces further cerebral damage. Acute thrombolysis or …

Stroke is a devastating disease associated with high mortality and disability worldwide, and
is generally classified as ischemic or hemorrhagic, which share certain similar …

There is a lack of effective therapies for stroke patients; its treatment is even more difficult
considering the unexpected onset of the disease. In the last decade, melatonin has emerged …

Melatonin is a potent antioxidant with neuroprotective activity in animal models of ischemic
stroke, which based on its lack of serious toxicity has raised hopes that it might be used for …

This article summarizes the evidence that endogenously produced and exogenously
administered melatonin reduces the degree of tissue damage and limits the biobehavioral …

This review summarizes the numerous reports that have documented the neuroprotective
actions of melatonin in experimental models of ischemia/reperfusion injury (stroke). In these …

Because of its favorable action profile in humans, melatonin is a particularly interesting
candidate as a neuroprotectant in acute ischemic stroke. Until now, the signaling …

Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …