The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …

DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

Methylated and non. methylated DNA sequences coexist in many animal gems. In
vertebrates most of the genome is methylated, and non. methylated sequences are reduced …

DNA methylation is a conspicuous feature of vertebrate genomes. Approximately 4% of total
cytosines are methylated, representing about 5 x 107 5-methylcytosine (5-mC) residues per …

De novo methylation of CpG islands within the promoters of eukaryotic genes is often
associated with their transcriptional repression, yet the methylation of CpG islands located …

CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …

DNA methylation plays an important role in the regulation of gene expression during
development. Methyl moieties at CpG residues suppress transcription by affecting DNA …

CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …

Despite the fact that 45% of all human gene promoters do not contain CpG islands, the role
of DNA methylation in control of non-CpG island promoters is controversial and its relevance …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …