Sex-specific programming of cardiac DNA methylation by developmental phthalate exposure

LK Svoboda, K Wang, RG Cavalcante… - Epigenetics …, 2020 - journals.sagepub.com
Phthalate plasticizers are ubiquitous chemicals linked to several cardiovascular diseases in
animal models and humans. Despite this, the mechanisms by which phthalate exposures …

Sex-specific alterations in cardiac DNA methylation in adult mice by perinatal lead exposure

LK Svoboda, K Wang, TR Jones, JA Colacino… - International journal of …, 2021 - mdpi.com
Environmental factors play an important role in the etiology of cardiovascular diseases.
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …

Perinatal DEHP exposure induces sex-and tissue-specific DNA methylation changes in both juvenile and adult mice

S Liu, K Wang, LK Svoboda, CA Rygiel… - Environmental …, 2021 - academic.oup.com
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a type of phthalate plasticizer found in a
variety of consumer products and poses a public health concern due to its metabolic and …

[HTML][HTML] Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver

Y Wen, S Rattan, JA Flaws, J Irudayaraj - Toxicology and applied …, 2020 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known
endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes …

Phthalate exposure changes the metabolic profile of cardiac muscle cells

NG Posnack, LM Swift, MW Kay, NH Lee… - Environmental health …, 2012 - ehp.niehs.nih.gov
Background: Phthalates are common plasticizers present in medical-grade plastics and
other everyday products. They can also act as endocrine-disrupting chemicals and have …

Phthalates in neonatal health: friend or foe?

JD Bowman, M Choudhury - … of Developmental Origins of Health and …, 2016 - cambridge.org
Exposure to environmental chemicals has adverse effects on the health and survival of
humans. Emerging evidence supports the idea that exposure to endocrine-disrupting …

[HTML][HTML] Translational toxicoepigenetic meta-analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead …

RL Petroff, DC Dolinoy, K Wang, L Montrose… - Environment …, 2024 - Elsevier
Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …

Impact of di‐ethylhexylphthalate exposure on metabolic programming in P19 ECC‐derived cardiomyocytes

K Schaedlich, JS Schmidt, WY Kwong… - Journal of Applied …, 2015 - Wiley Online Library
Abstract Di (2‐ethylhexyl) phthalate (DEHP) is the most common plasticizer in plastic
devices of everyday use. It is a ubiquitous environmental contaminant and primarily known …

Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations

LK Svoboda, T Ishikawa… - Environmental epigenetics, 2022 - academic.oup.com
Despite substantial strides in diagnosis and treatment, cardiovascular diseases (CVDs)
continue to represent the leading cause of death in the USA and around the world, resulting …

Association between fetal exposure to phthalate endocrine disruptor and genome-wide DNA methylation at birth

CH Chen, SS Jiang, IS Chang, HJ Wen, CW Sun… - Environmental …, 2018 - Elsevier
Background Phthalic acid esters are ubiquitous and antiandrogenic, and may cause
systemic effects in humans, particularly with in utero exposure. Epigenetic modification, such …