Sex-specific programming of cardiac DNA methylation by developmental phthalate exposure
LK Svoboda, K Wang, RG Cavalcante… - Epigenetics …, 2020 - journals.sagepub.com
Phthalate plasticizers are ubiquitous chemicals linked to several cardiovascular diseases in
animal models and humans. Despite this, the mechanisms by which phthalate exposures …
animal models and humans. Despite this, the mechanisms by which phthalate exposures …
Sex-specific alterations in cardiac DNA methylation in adult mice by perinatal lead exposure
Environmental factors play an important role in the etiology of cardiovascular diseases.
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …
Perinatal DEHP exposure induces sex-and tissue-specific DNA methylation changes in both juvenile and adult mice
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a type of phthalate plasticizer found in a
variety of consumer products and poses a public health concern due to its metabolic and …
variety of consumer products and poses a public health concern due to its metabolic and …
[HTML][HTML] Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver
Abstract Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known
endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes …
endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes …
Phthalate exposure changes the metabolic profile of cardiac muscle cells
Background: Phthalates are common plasticizers present in medical-grade plastics and
other everyday products. They can also act as endocrine-disrupting chemicals and have …
other everyday products. They can also act as endocrine-disrupting chemicals and have …
Phthalates in neonatal health: friend or foe?
JD Bowman, M Choudhury - … of Developmental Origins of Health and …, 2016 - cambridge.org
Exposure to environmental chemicals has adverse effects on the health and survival of
humans. Emerging evidence supports the idea that exposure to endocrine-disrupting …
humans. Emerging evidence supports the idea that exposure to endocrine-disrupting …
[HTML][HTML] Translational toxicoepigenetic meta-analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead …
Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …
critical translational gap between laboratory-based studies and epidemiology remains. In …
Impact of di‐ethylhexylphthalate exposure on metabolic programming in P19 ECC‐derived cardiomyocytes
K Schaedlich, JS Schmidt, WY Kwong… - Journal of Applied …, 2015 - Wiley Online Library
Abstract Di (2‐ethylhexyl) phthalate (DEHP) is the most common plasticizer in plastic
devices of everyday use. It is a ubiquitous environmental contaminant and primarily known …
devices of everyday use. It is a ubiquitous environmental contaminant and primarily known …
Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations
LK Svoboda, T Ishikawa… - Environmental epigenetics, 2022 - academic.oup.com
Despite substantial strides in diagnosis and treatment, cardiovascular diseases (CVDs)
continue to represent the leading cause of death in the USA and around the world, resulting …
continue to represent the leading cause of death in the USA and around the world, resulting …
Association between fetal exposure to phthalate endocrine disruptor and genome-wide DNA methylation at birth
CH Chen, SS Jiang, IS Chang, HJ Wen, CW Sun… - Environmental …, 2018 - Elsevier
Background Phthalic acid esters are ubiquitous and antiandrogenic, and may cause
systemic effects in humans, particularly with in utero exposure. Epigenetic modification, such …
systemic effects in humans, particularly with in utero exposure. Epigenetic modification, such …