The DNA methylome is re-patterned during discrete phases of vertebrate development. In
zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

We have examined the methylation status of the zebrafish genome during early
embryogenesis and we find evidence that methylation fluxes do occur in that organism. The …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

Background Multicellular organisms require precise gene regulation during ontogeny, and
epigenetic modifications, such as DNA methylation and histone modification, facilitate this …

DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …

Embryo development proceeds from a cascade of gene activation and repression events
controlled by epigenetic modifications of DNA and histones. Little is known about epigenetic …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

DNA methylation constitutes an important epigenetic factor in the control of genetic
information. In this study, we analyzed expression of the DNA methyltransferase gene and …

DNA methylation is a fundamental epigenetic modification in vertebrate genomes and a
small fraction of genomic regions is hypomethylated. Previous studies have implicated …