The complex processes necessary for embryogenesis require a gene regulatory network
that is complex and systematic. Gene expression regulates development and …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …

methylcytosine is a major epigenetic modification that is sometimes called" the fifth
nucleotide." However, our knowledge of how offspring inherit the DNA methylome from …

Background Enhancers, not promoters, are the most dynamic in their DNA methylation
status throughout development and differentiation. Generally speaking, enhancers that are …

Genomic DNA methylation functions to repress gene expression by interfering with
transcription factor binding and/or recruiting repressive chromatin machinery. Recent data …

Early embryonic development is crucially important but also remarkably diverse among
animal taxa. Axis formation and cell lineage specification occur due to both spatial and …

DNA methylation is crucial for normal development and cellular differentiation in many large-
genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently …

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …

Methylation of cytosines in the CG context (mCG) is the most abundant DNA modification in
vertebrates that plays crucial roles in cellular differentiation and identity. After fertilization …

Genome-wide profiling of DNA methylation and histone modifications answered many
questions as to how the genes are regulated on a global scale and what their epigenetic …