Although it is well known that DNA methylation serves to repress gene expression, precisely
how it functions during the process of development remains unclear. Here, we propose that …

Marked epigenetic reprogramming is essential to convert terminally differentiated gametes
to totipotent embryos. It remains puzzling why postfertilization global DNA reprogramming …

A characteristic of anamniote development is a relatively long period of embryonic cell
divisions in the absence of on-going transcription. In zebrafish, this period lasts for 10 cell …

Background DNA methylation is an epigenetic modification that is ubiquitous across many
eukaryotes, with variable patterns and functions across taxa. The roles of DNA methylation …

Reversible covalent histone modifications are known to influence spatiotemporal patterns of
gene transcription during development. Here I review recent advances in the development …

DNA methylation plays crucial roles during embryonic development. Here we present
MethBank (http://dnamethylome. org), a DNA methylome programming database that …

DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate
genomes, yet the developmental dynamics in which 5mC patterns are established vary …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

Background Methylation of cytosines in DNA (5mC methylation) is a major epigenetic
modification that modulates gene expression and constitutes the basis for mechanisms …

5-methylcytosine (5mC) is the best understood DNA modification and is generally believed
to be associated with repression of gene expression. Over the last decade, sequentially …