An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs
essential for cellular function. The genome also harbors cis-acting non-coding sequences …

DNA methylation of transcription units (gene bodies) occurs in the genomes of many animal
and plant species. Phylogenetic persistence of gene body methylation implies biological …

Genomes of invertebrates and vertebrates exhibit highly divergent patterns of DNA
methylation. Invertebrate genomes tend to be sparsely methylated, and DNA methylation is …

DNA methylation has the ability to repress transcription; in addition, the pattern of
methylation can be stably inherited during successive cell divisions [1]. These two features …

The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA
methylation whereas invertebrate genomes are less methylated, predominantly within gene …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Background Epigenetic processes are proposed to be a mechanism regulating gene
expression during phenotypic plasticity. However, environmentally induced changes in DNA …

Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …