Nanomedicines for pediatric cancers

C Rodriguez-Nogales, Y Gonzalez-Fernandez… - ACS …, 2018 - ACS Publications
Chemotherapy protocols for childhood cancers are still problematic due to the high toxicity
associated with chemotherapeutic agents and incorrect dosing regimens extrapolated from …

Tumor microenvironment‐regulating nanomedicine design to fight multi‐drug resistant tumors

Q Xu, X Lan, H Lin, Q Xi, M Wang… - Wiley …, 2023 - Wiley Online Library
The tumor microenvironment (TME) is a very cunning system that enables tumor cells to
escape death post‐traditional antitumor treatments through the comprehensive effect of …

Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

G Lu, X Wang, F Li, S Wang, J Zhao, J Wang… - Nature …, 2022 - nature.com
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few
treatment options. Here, building on the observation of elevated lactate (LA) in resected …

[HTML][HTML] Molecular-targeted nanotherapies in cancer: enabling treatment specificity

E Blanco, A Hsiao, GU Ruiz-Esparza, MG Landry… - Molecular …, 2011 - Elsevier
Chemotherapy represents a mainstay and powerful adjuvant therapy in the treatment of
cancer. The field has evolved from drugs possessing all-encompassing cell-killing effects to …

Advances in nano drugs for cancer chemotherapy

I Ali, K Salim, MA Rather, WA Wani… - Current cancer drug …, 2011 - ingentaconnect.com
In spite of some medications, millions of people are dying every year due to cancer.
Additionally, the survival patients suffer from various serious side effects due to the use of …

Above and beyond cancer therapy: translating biomaterials into the clinic

J Conde - Trends in Cancer, 2020 - cell.com
Given extensive reports of anticancer nanomedicines in preclinical studies, why is there
such a paucity of clinical trials using these therapies? Nanotechnology can certainly deliver …

Nanoparticle strategies to improve the delivery of anticancer drugs across the blood–brain barrier to treat brain tumors

WJF Vanbilloen, JS Rechberger, JB Anderson… - Pharmaceutics, 2023 - mdpi.com
Primary brain and central nervous system (CNS) tumors are a diverse group of neoplasms
that occur within the brain and spinal cord. Although significant advances in our …

Theranostic nanomedicine for malignant gliomas

M d'Angelo, V Castelli, E Benedetti… - … in bioengineering and …, 2019 - frontiersin.org
Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant
gliomas represent an incurable disease; indeed, after surgery and chemotherapy …

Nanomedicine in cancer therapy: innovative trends and prospects

E Blanco, A Hsiao, AP Mann, MG Landry… - Cancer …, 2011 - Wiley Online Library
Cancer is a leading cause of morbidity and mortality worldwide, with recent advancements
resulting in modest impacts on patient survival. Nanomedicine represents an innovative field …

Nanodelivery systems: An efficient and target‐specific approach for drug‐resistant cancers

S Ashique, A Garg, A Hussain, A Farid… - Cancer …, 2023 - Wiley Online Library
Background Cancer treatment is still a global health challenge. Nowadays, chemotherapy is
widely applied for treating cancer and reducing its burden. However, its application might be …