[HTML][HTML] Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

JP Gouin, QQ Zhou, L Booij, M Boivin, SM Côté… - Scientific Reports, 2017 - nature.com
Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as
a molecular mechanism underlying the increased risk of mental disorder associated with …

Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation

E Unternaehrer, M Bolten, I Nast… - Social cognitive and …, 2016 - academic.oup.com
The aim of this study was to investigate whether maternal adversities and cortisol levels
during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We …

[HTML][HTML] The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …

DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology

K Lancaster, L Goldbeck, MH Puglia… - Social cognitive and …, 2018 - academic.oup.com
Oxytocin has anxiolytic properties whose mechanisms of action are still being identified.
DNA methylation in the promoter region of the oxytocin receptor gene (OXTR), an epigenetic …

Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children

L King, S Robins, G Chen, V Yerko, Y Zhou… - Hormones and …, 2017 - Elsevier
The present study investigated the association of perinatal depression (PD) with differential
methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin …

Relation of promoter methylation of the oxytocin gene to stressful life events and depression severity

S Sanwald, M Gahr, K Widenhorn-Müller… - Journal of Molecular …, 2020 - Springer
Oxytocin (OT) is a neuropeptide associated with trauma, sociality, and depression. Despite
the widely accepted assumption of OT playing a role in the etiology of mood and anxiety …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness

P Toepfer, KJ O'Donnell, S Entringer, E Garg… - …, 2019 - Elsevier
Maternal behavior (MB) is observable across mammals and represents an important feature
of environmental variation during early postnatal development. Oxytocin (OT) plays a crucial …

Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood

NC Ebner, T Lin, M Muradoglu, DH Weir… - International Journal of …, 2019 - Elsevier
The neuropeptide oxytocin (OT) has been implicated in a wide range of affiliative processes.
OT exerts its functions via OT receptors, which are encoded by the oxytocin receptor gene …

[HTML][HTML] Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

JS Danoff, KL Wroblewski, AJ Graves, GC Quinn… - Clinical …, 2021 - Springer
Background The neuropeptide oxytocin regulates mammalian social behavior. Disruptions
in oxytocin signaling are a feature of many psychopathologies. One commonly studied …