Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

Understanding how the epigenetic blueprint of the genome shapes human phenotypes
requires systematic evaluation of the complex interplay between gene activity and the …

Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …

Purpose: Aging is one of the most important risk factors for a number of human diseases.
Epigenetic alterations, including changes in DNA methylation patterns, have been reported …

Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …

Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

The number of epigenetic studies is exponentially increasing. There is anticipation that DNA
methylation may close gaps in our understanding of disease etiology, and how certain risk …

DNA methylation plays a critical role in the regulation of gene expression. The ability to
access the methylation status for a large number of genes or the entire genome should …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …