DNA methylation is an epigenetic modification that plays an important role in gene
regulation. It can be influenced by stochastic events, environmental factors and …

In mammals, DNA methylation profiles vary substantially between tissues. Recent genome-
scale studies report that blood displays a highly distinctive methylomic profile from other …

The prevalence and severity of many diseases differs by sex, potentially due to sex-specific
patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have …

Epigenetics is emerging as an attractive mechanism to explain the persistent genomic
embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into …

DNA methylation is assumed to be complementary on both alleles across the genome,
although there are exceptions, notably in regions subject to genomic imprinting. We present …

DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

Background The functional impact of genetic variation has been extensively surveyed,
revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic …

There is increasing interest in understanding the potential for epigenetic factors to contribute
to phenotypic diversity in evolutionary biology. One well studied epigenetic mechanism is …

Imprinted genes are vulnerable to environmental influences during early embryonic
development, thereby contributing to the onset of disease in adulthood. Monoallelic …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …