Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

Alterations in DNA methylation have been reported to occur during development and aging;
however, much remains to be learned regarding post-natal and age-associated epigenome …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

DNA methylation is an epigenetic modification, influenced by both genetic and
environmental variation, that plays a key role in transcriptional regulation and many …

Epigenetics describes the study of cellular modifications that can modify the expression of
genes without changing the DNA sequence. DNA methylation is one of the most stable and …

DNA methylation, genotype and gene expression: who is driving and who is along for the ride?
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Background DNA methylation is a contributing factor to both rare and common human
diseases, and plays a major role in development and gene silencing. While the variation of …

Epigenetic changes are required for normal development, yet the nature and respective
contribution of factors that drive epigenetic variation in humans remain to be fully …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Methylation at CpG dinucleotides is important for gene regulation in mammals [1]. However,
it is unknown how methylation patterns change during evolution. Here, we compare …