Epigenetic changes represent a potential mechanism underlying associations of early-life
exposures and later life health outcomes. Population-based cohort studies starting in early …

Nutrition has always played an important role in health and disease, ranging from common
diseases to its likely contribution to the fetal origins of adult disease. However, deciphering …

Background Disease risk and incidence between males and females reveal differences, and
sex is an important component of any investigation of the determinants of phenotypes or …

The prospect of finding epigenetic risk factors for complex diseases would be greatly
enhanced if DNA from existing biobanks, which is generally extracted from whole blood …

While population studies have resulted in detailed maps of genetic variation in humans, to
date there are few robust maps of epigenetic variation. We identified sites containing …

Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …

Background Disadvantaged socio-economic position (SEP) in childhood is associated with
increased adult mortality and morbidity. We aimed to establish whether childhood SEP was …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …

DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …