Adjusting for cell type composition in DNA methylation data using a regression-based approach
Abstract Analysis of DNA methylation in a population context has the potential to uncover
novel gene and environment interactions as well as markers of health and disease. In order …
novel gene and environment interactions as well as markers of health and disease. In order …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
[HTML][HTML] Influence of genetic background and tissue types on global DNA methylation patterns
HH Yang, N Hu, C Wang, T Ding, BK Dunn… - PLoS …, 2010 - journals.plos.org
Recent studies have shown a genetic influence on gene expression variation, chromatin,
and DNA methylation. However, the effects of genetic background and tissue types on DNA …
and DNA methylation. However, the effects of genetic background and tissue types on DNA …
[HTML][HTML] Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal
disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG …
disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG …
[HTML][HTML] DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
Intra-individual change over time in DNA methylation with familial clustering
Context Changes over time in epigenetic marks, which are modifications of DNA such as by
DNA methylation, may help explain the late onset of common human diseases. However …
DNA methylation, may help explain the late onset of common human diseases. However …
The methylome: approaches for global DNA methylation profiling
S Beck, VK Rakyan - Trends in Genetics, 2008 - cell.com
DNA methylation plays a critical role in genome function both in health and disease. Almost
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …
Genome-wide quantification of the effects of DNA methylation on human gene regulation
Changes in DNA methylation are involved in development, disease, and the response to
environmental conditions. However, not all regulatory elements are functionally methylation …
environmental conditions. However, not all regulatory elements are functionally methylation …
Analysing and interpreting DNA methylation data
C Bock - Nature Reviews Genetics, 2012 - nature.com
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …
of biological processes and diseases. The technology is now available for studying DNA …
DNA methylation methods: Global DNA methylation and methylomic analyses
S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …
significant involvement for numerous biological processes in health and disease. The …