DNA methylation is assumed to be complementary on both alleles across the genome,
although there are exceptions, notably in regions subject to genomic imprinting. We present …

Epigenetics is emerging as an attractive mechanism to explain the persistent genomic
embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into …

Background The functional impact of genetic variation has been extensively surveyed,
revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic …

There is increasing interest in understanding the potential for epigenetic factors to contribute
to phenotypic diversity in evolutionary biology. One well studied epigenetic mechanism is …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

Populations are often divided categorically into distinct racial/ethnic groups based on social
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …

Alterations in epigenetic landscapes are hallmarks of many complex human diseases, yet, it
is often challenging to assess the underlying mechanisms and causal link with clinical …

Ethnic differences in non-communicable disease risk have been described between
individuals of South Asian and European ethnicity that are only partially explained by …

Inter-individual DNA methylation variations were frequently hypothesized to alter individual
susceptibility to Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations were …