[HTML][HTML] An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
episodic psychosis and altered cognitive function. Despite success in identifying genetic …
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
J Viana, E Hannon, E Dempster… - Human molecular …, 2017 - academic.oup.com
Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
[HTML][HTML] Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …
result from disturbances in early brain development. There is mounting evidence to support …
[HTML][HTML] Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
Association of DNA methylation differences with schizophrenia in an epigenome-wide association study
Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …
[HTML][HTML] DNA methylation in schizophrenia: progress and challenges of epigenetic studies
Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population,
with significant effects on patients and society. Genetic studies have identified several …
with significant effects on patients and society. Genetic studies have identified several …
Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future
Increased understanding about the functional complexity of the genome has led to growing
recognition about the role of epigenetic variation in the etiology of schizophrenia. Epigenetic …
recognition about the role of epigenetic variation in the etiology of schizophrenia. Epigenetic …
[HTML][HTML] Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …
and bipolar disorder. To date, however, few studies have investigated the role of DNA …
[HTML][HTML] Cell type-specific epigenetic links to schizophrenia risk in the brain
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
[HTML][HTML] DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …