Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …

Background Genetic influence on DNA methylation is potentially an important mechanism
affecting individual differences in humans. We use next-generation sequencing to assay …

Inherited genetic variation affects local gene expression and DNA methylation in humans.
Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a …

DNA methylation is an important molecular-level phenotype that links genotypes and
complex disease traits. Previous studies have found local correlation between genetic …

Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …

Background Epigenome-wide association studies using DNA methylation have the potential
to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk …

Little is known about the extent to which interactions between genetics and epigenetics may
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …