Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney …
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice
W Zhang, A Miikeda, J Zuckerman, X Jia… - Scientific Reports, 2021 - nature.com
Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …
Trimethylamine N-oxide and risk of cardiovascular disease and mortality
Abstract Purpose of Review Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent
metabolite produced from choline and phosphatidylcholine. Trimethylamine N-oxide was …
metabolite produced from choline and phosphatidylcholine. Trimethylamine N-oxide was …
Targeted inhibition of gut microbial trimethylamine N-oxide production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic …
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
[HTML][HTML] The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease
JAP Tomlinson, DC Wheeler - Kidney international, 2017 - Elsevier
Patients with chronic kidney disease (CKD) have an enhanced risk of cardiovascular (CV)
morbidity and mortality when compared with age-and gender-matched individuals with …
morbidity and mortality when compared with age-and gender-matched individuals with …
Elevation of trimethylamine-N-oxide in chronic kidney disease: contribution of decreased glomerular filtration rate
CC Pelletier, M Croyal, L Ene, A Aguesse… - Toxins, 2019 - mdpi.com
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly
linked to renal function and to increased cardiovascular events in the general population …
linked to renal function and to increased cardiovascular events in the general population …
Associations of trimethylamine N-oxide with nutritional and inflammatory biomarkers and cardiovascular outcomes in patients new to dialysis
GA Kaysen, KL Johansen, GM Chertow… - Journal of Renal …, 2015 - Elsevier
Objectives Trimethylamine N-oxide (TMAO) is a product of metabolism of
phosphatidylcholine (lecithin) and carnitine by the intestinal microbiome. Elevated serum …
phosphatidylcholine (lecithin) and carnitine by the intestinal microbiome. Elevated serum …
[HTML][HTML] Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
RB Kim, BL Morse, O Djurdjev, M Tang, N Muirhead… - Kidney international, 2016 - Elsevier
Cardiovascular disease is more common in patients with chronic kidney disease (CKD), and
traditional risk factors do not adequately predict those at risk for cardiovascular (CV) events …
traditional risk factors do not adequately predict those at risk for cardiovascular (CV) events …
[HTML][HTML] Gut microbiota-derived trimethylamine N-oxide and kidney function: a systematic review and meta-analysis
Y Zeng, M Guo, X Fang, F Teng, X Tan, X Li, M Wang… - Advances in …, 2021 - Elsevier
Elevated circulating trimethylamine N-oxide (TMAO) concentrations have been observed in
patients with chronic kidney disease (CKD). We aimed to systematically estimate and …
patients with chronic kidney disease (CKD). We aimed to systematically estimate and …
Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients
KY Xu, GH Xia, JQ Lu, MX Chen, X Zhen, S Wang… - Scientific Reports, 2017 - nature.com
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …
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