CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

Two-thirds of gene promoters in mammals are associated with regions of non-methylated
DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation …

Mammalian CpG islands are key epigenomic elements that were first characterized
experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …

Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been
shown that some vertebrate genes contain CpG islands, regions of DNA with a high G+ C …

The primary target for DNA methylation in mammalian genomes is cytosine in the
dinucleotide CpG. High densities of CpG dinucleotides are found in CpG islands, but …

Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in
CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is …

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine
base in the context of CpG dinucleotides. This modification creates a binding site for MBD …