DNA is methylated at the dinucleotide CpG in genomes of a wide range of plants and
animals. Among animals, variable patterns of genomic CpG methylation have been …

The 5'region of the gene encoding human X chromosome-linked phosphoglycerate kinase 1
(PGK1) is a promoter-containing CpG island known to be methylated at 119 of 121 CpG …

We have investigated the distribution of unmethylated CpG islands in vertebrate genomes
fractionated according to their base composition. Genomes from warm-blooded vertebrates …

CpG islands (CGI) are genomic regions associated with gene promoters and involved in
gene expression regulation. Despite their high CpG content and unlike bulk genomic DNA …

A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …

The majority of mammalian promoters are CpG islands; regions of high CG density that
require protection from DNA methylation to be functional. Importantly, how sequence …

Background CpG islands, which are clusters of CpG dinucleotides in GC-rich regions, are
considered gene markers and represent an important feature of mammalian genomes …

Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases
in vertebrate genomes, has been constrained by their evolutionary instability and by the …

CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …

Background Transgenes are often engineered using regulatory elements from distantly
related genomes. Although correct expression patterns are frequently achieved even in …