High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
F Antequera, J Boyes, A Bird - Cell, 1990 - cell.com
CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
DNA methylation in human epigenomes depends on local topology of CpG sites
In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and
heritable patterns of gene expression. The classical model for inheritance, in which …
heritable patterns of gene expression. The classical model for inheritance, in which …
A CpG island-encoded mechanism protects genes from premature transcription termination
AL Hughes, AT Szczurek, JR Kelley… - Nature …, 2023 - nature.com
Transcription must be tightly controlled to regulate gene expression and development.
However, our understanding of the molecular mechanisms that influence transcription and …
However, our understanding of the molecular mechanisms that influence transcription and …
CG methylation
C Vinson, R Chatterjee - Epigenomics, 2012 - Taylor & Francis
A striking feature of mammalian genomes is the paucity of the CG dinucleotide. There are
approximately 20,000 regions termed CpG islands where CGs cluster. This represents 5% of …
approximately 20,000 regions termed CpG islands where CGs cluster. This represents 5% of …
Smchd1-dependent and-independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome
AV Gendrel, A Apedaile, H Coker, A Termanis… - Developmental cell, 2012 - cell.com
X chromosome inactivation involves multiple levels of chromatin modification, established
progressively and in a stepwise manner during early development. The chromosomal …
progressively and in a stepwise manner during early development. The chromosomal …
A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q
Y Yamada, H Watanabe, F Miura, H Soejima… - Genome …, 2004 - genome.cshlp.org
Approximately half of all human genes have CpG islands (CGIs) around their promoter
regions. Although CGIs usually escape methylation, those on Chromosome X in females …
regions. Although CGIs usually escape methylation, those on Chromosome X in females …
Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein
DL Carlone, JH Lee, SRL Young… - … and cellular biology, 2005 - Taylor & Francis
Cytosine methylation at CpG dinucleotides is a critical epigenetic modification of mammalian
genomes. CpG binding protein (CGBP) exhibits a unique DNA-binding specificity for …
genomes. CpG binding protein (CGBP) exhibits a unique DNA-binding specificity for …
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …
interest, but remains poorly understood. We performed comprehensive DNA methylation …
Intergenic, gene terminal, and intragenic CpG islands in the human genome
Background Recently, it has been discovered that the human genome contains many
transcription start sites for non-coding RNA. Regulatory regions related to transcription of …
transcription start sites for non-coding RNA. Regulatory regions related to transcription of …
Purification of CpG islands using a methylated DNA binding column
CpG islands are short stretches of DNA containing a high density of non–methylated CpG
dinucleotides, predominantly associated with coding regions. We have constructed an …
dinucleotides, predominantly associated with coding regions. We have constructed an …