De novo methylation of CpG islands within the promoters of eukaryotic genes is often
associated with their transcriptional repression, yet the methylation of CpG islands located …

Promoters are molecular 'modules', which are controlled as individual entities yet are often
analyzed by nuclease digestion methodologies which, a priori, destroy this modularity …

Elucidating how and to what extent CpG islands (CGIs) are methylated in germ cells is
essential to understand genomic imprinting and epigenetic reprogramming,,. Here we …

Background CpG islands and nucleosome-free regions are both found in promoters.
However, their association has never been studied. On the other hand, DNA methylation is …

A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …

DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

Methylation of CpG-dinucleotides within proximal promoters is often associated with
transcriptional silencing. Methylation-dependent repression is well established for …

Instructive mechanisms are present for induction of DNA methylation, as shown by
methylation of specific CpG islands (CGIs) by specific inducers and in specific cancers …

The majority of gene transcripts generated by RNA polymerase II in mammalian genomes
initiate at CpG island (CGI) promoters,, yet our understanding of their regulation remains …

Of the estimated 45 000 CpG islands in the human genome, the overwhelming majority are
found at the 5′ ends of genes and their identification and cloning are proving very useful for …