Polycystic kidney disease (PKD), in which epithelial cysts arise from or instead of normal
renal tubules, is one of the most common genetic diseases. It has both autosomal dominant …

Renal cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is
characterized by increased epithelial cell proliferation and fluid accumulation. Using …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Polycystic kidney disease is an inherited disorder of parenchymal structure that leads to
renal failure. Cysts begin as focal dilations in proximal tubules and collecting ducts, giving …

Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular
differentiation? Polycystic kidney disease (PKD) is inherited as a dominant or recessive trait …

This short review summarizes some information concerning what is known about matrix
adhesion molecules, focal adhesion proteins, and cell-cell adhesion molecules in normal …

Mutations in the PKD1 gene are responsible for autosomal dominant polycystic kidney
disease (ADPKD). Although PKD1 has been cloned and shown to be expressed at high …

Impaired tubulogenesis of cyst-derived cells from autosomal dominant polycystic kidneys.
Under appropriate growth factor or hormonal influence, renal epithelial cells cultured in …

The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears
similar in many respects to that seen in the autosomal dominant form of human polycystic …

Changes of extracellular matrix are involved in the pathogenesis of autosomal dominant
polycystic kidney disease (ADPKD). The relationship between epithelial changes and …