Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis

IV Yang, BS Pedersen, E Rabinovich… - American journal of …, 2014 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease
that is increasing in prevalence and is caused by complex interactions between genetic and …

Altered DNA methylation profile in idiopathic pulmonary fibrosis

YY Sanders, N Ambalavanan, B Halloran… - American journal of …, 2012 - atsjournals.org
Rationale: DNA methylation is an important epigenetic mechanism, which often occurs in
response to environmental stimuli and is crucial in regulating gene expression. It is likely …

Epigenetics Approaches toward Precision Medicine for Idiopathic Pulmonary Fibrosis: Focus on DNA Methylation

WI Effendi, T Nagano - Biomedicines, 2023 - mdpi.com
Genetic information is not transmitted solely by DNA but by the epigenetics process.
Epigenetics describes molecular missing link pathways that could bridge the gap between …

Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung

SK Huang, AM Scruggs, RC McEachin, ES White… - PloS one, 2014 - journals.plos.org
Excessive fibroproliferation is a central hallmark of idiopathic pulmonary fibrosis (IPF), a
chronic, progressive disorder that results in impaired gas exchange and respiratory failure …

Global methylation patterns in idiopathic pulmonary fibrosis

EI Rabinovich, MG Kapetanaki, I Steinfeld, KF Gibson… - PloS one, 2012 - journals.plos.org
Background Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the
lung phenotype including excessive extracellular matrix deposition, myofibroblast foci …

DNA methylation in pulmonary fibrosis and lung cancer

J Duan, B Zhong, Z Fan, H Zhang, M Xu… - Expert review of …, 2022 - Taylor & Francis
Introduction Pulmonary fibrosis is an age-related, progressive, and fatal disease with a
median survival of 3–5 years after diagnosis; idiopathic pulmonary fibrosis (IPF) is the most …

Molecular signatures of idiopathic pulmonary fibrosis

IR Konigsberg, R Borie, AD Walts… - American journal of …, 2021 - atsjournals.org
Molecular patterns and pathways in idiopathic pulmonary fibrosis (IPF) have been
extensively investigated, but few studies have assimilated multiomic platforms to provide an …

Epigenetics in lung fibrosis: from pathobiology to treatment perspective

BA Helling, IV Yang - Current opinion in pulmonary medicine, 2015 - journals.lww.com
Although we are in very early stages of understanding the role of epigenetics in IPF, the
potential for the use of epigenetic marks as biomarkers and therapeutic targets is high and …

[HTML][HTML] Impact of transcriptomics on our understanding of pulmonary fibrosis

M Vukmirovic, N Kaminski - Frontiers in medicine, 2018 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant
remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung …

Epigenetics in idiopathic pulmonary fibrosis

A Tzouvelekis, N Kaminski - Biochemistry and Cell Biology, 2015 - cdnsciencepub.com
Idiopathic pulmonary fibrosis (IPF) is a lethal chronic lung disorder with no effective
treatment and a prognosis worse than that of lung cancer. Despite extensive research …