Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …

Recent studies show that subtle variations in thyroid function, including subclinical thyroid
dysfunction, and even variation in thyroid function within the normal range, are associated …

Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …

Objectives Previous studies have shown interindividual variation in free thyroxine (FT4)
serum levels and thyroid stimulating hormone (TSH) in healthy persons. Genetic factors …

Objective Genome-wide association studies in adults have identified 42 loci associated with
thyroid stimulating hormone (TSH) and 21 loci associated with free thyroxine (FT4) …

Background: The thyroid plays a key role in development and homeostasis, but it has been
difficult to establish causality with diseases and phenotypic traits because of several …

Thyroid dysfunction is a common endocrine disease measured by thyroid-stimulating
hormone (TSH) level. Although> 70 genetic loci associated with TSH have been reported …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …