Variation in gene expression is an important feature of mouse embryonic stem cells (ESCs).
However, the mechanisms responsible for global gene expression variation in ESCs are not …

Human embryonic stem cells (hESCs) are an important source of stem cells in regenerative
medicine, and much remains unknown about their molecular characteristics. To develop a …

Background Gene expression heterogeneity contributes to development as well as disease
progression. Due to technological limitations, most studies to date have focused on …

Background Human embryonic stem (ES) cells hold great promise for medicine and science.
The transcriptome of human ES cells has been studied in detail in recent years. However, no …

During the transition from the inner cell mass (ICM) cells of blastocysts to pluripotent
embryonic stem cells (ESCs) in vitro, a normal developmental program is replaced in cells …

An understanding of the regulatory mechanisms responsible for pluripotency in embryonic
stem cells (ESCs) is critical for realizing their potential in medicine and science. Significant …

Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation
embryo. Here we assess the impact of derivation and culture conditions on both functional …

Human embryonic stem cells (hESCs) have the potential to form any cell type in the body,
making them attractive cell sources in drug screening, regenerative medicine, disease and …

Stem cell differentiation involves critical changes in gene expression. Identification of these
should provide endpoints useful for optimizing stem cell propagation as well as potential …

Epigenetic mechanisms, such as histone modifications and DNA methylation, have been
shown to play a key role in the regulation of gene transcription. Results of recent studies …